Development of an angiogenesis-targeted microbubble ultrasound contrast agent
نویسندگان
چکیده
منابع مشابه
Detection of Microbubble Ultrasound Contrast Agent Destruction Applied to Definity
For different applications such as imaging, drug delivery and tissue perfusion measurement, it is necessary to know the inertial cavitation (IC) threshold of ultrasonic contrast agent (UCA) microbubbles. The IC threshold for Definity R © was determined using a passive cavitation detection (PCD) system. The IC threshold criterion was rebound. The incident ultrasonic field at a constant pulse rep...
متن کاملRGD-Targeted Ultrasound Contrast Agent for Longitudinal Assessment of Hep-2 Tumor Angiogenesis In Vivo.
OBJECTIVE To prepare arginine-glycine-aspartate (RGD)-targeted ultrasound contrast microbubbles (MBs) and explore the feasibility of their use in assessing dynamic changes in αvβ3 integrin expression in a murine model of tumor angiogenesis. METHODS RGD peptides were conjugated to the surfaces of microbubbles via biotin-avidin linkage. Microbubbles bearing RADfK peptides were prepared as contr...
متن کاملMicrobubble ultrasound contrast agents: a review.
The superior scattering properties of gas bubbles compared with blood cells have made microbubble ultrasound contrast agents important tools in ultrasound diagnosis. Over the past 2 years they have become the focus of a wide and rapidly expanding field of research, with their benefits being repeatedly demonstrated, both in ultrasound image enhancement, and more recently in drug and gene deliver...
متن کاملNew Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction
Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, d...
متن کاملUltrasound combined with targeted cationic microbubble-mediated angiogenesis gene transfection improves ischemic heart function
The present study aimed to construct targeted cationic microbubbles (TCMBs) by synthesizing cationic microbubbles conjugated to an intercellular adhesion molecule-1 (ICAM-1) antibody, and then to use the TCMBs to deliver the angiopoietin-1 (Ang-1) gene into infarcted heart tissue using ultrasound-mediated microbubble destruction. It was hypothesized that the TCMBs would accumulate in higher num...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)81616-3